Xeloda® (capecitabine) is a Prescription Medicine used to treat bowel and rectum (colorectal), oesophagus, stomach and breast cancer. Xeloda may be used alone or in combination with other cancer medicines.Xeloda should not be taken if you: have had a reaction in the past to any of the ingredients in Xeloda, have severe kidney disease, are taking a medicine called sorivudine or brivudine, or have allergies to other fluoropyrimidine medicines such as 5-fluorouracil, have dihydropyrimidine dehydrogenase (DPD) deficiency. Tell your doctor if you: are pregnant or breastfeeding, have heart, liver, or kidney disease; diarrhoea or dehydration. Signs of dehydration include dry skin, dark coloured urine, thirst, weakness or fatigue, loss of appetite. Possible unwanted effects: Common: tiredness, weakness; rash, dry or itchy skin; abdominal (gut) pain; fever; constipation; headache; dizziness; reduced appetite, weight loss; hair loss; watery or irritated eyes; taste disturbance; indigestion; dry mouth; nail disorders; sore throat, cough, nose bleeds; shortness of breath; muscle and joint pain. Serious (common): severe diarrhoea, nausea, or vomiting; pain, redness, swelling of hands/feet (hand-foot-syndrome); pain, redness, swelling or sores in the mouth (stomatitis). Serious (rare): chest pain; irregular heart beat; confusion; poor balance or lack of co-ordination; blood in the faeces; signs of infection (fever, redness) or liver disease (yellow eyes/skin). Ask your oncologist if Xeloda is right for you. Use strictly as directed. If symptoms continue or you experience side-effects or would like further information, please talk to your oncologist or visit www.medsafe.govt.nz for Xeloda Consumer Medicines Information. Xeloda (150mg and 500mg tablets) is a funded medicine for patients who meet pre-defined criteria. A prescription charge and normal oncologist’s fees may apply.
What is gastric cancer?
Gastric (stomach) cancer, is a disease in which stomach cells become cancerous and grow out of control, eventually forming a tumour. Although it is often referred to as stomach cancer, it can involve tumours that occur in the oesophagus (the tube that runs from your mouth to your stomach) as well. Because of this it is sometimes referred to as oesophagogastric cancer.
Gastric cancer is the second-leading cause of cancer deaths in the world, and around 350 New Zealanders will be diagnosed with it each year. It is more common in people over the age of 55 years and affects twice as many men as women.
Diagnosing gastric and oesophageal cancers
These types of cancers can be very difficult to detect and diagnose, as there are few symptoms in the early stages.
Most diagnoses are made at an advanced stage, where symptoms include:
- Discomfort in the upper or middle part of the abdomen
- Difficulty swallowing
- Blood in the stools (which appear as black, tarry stools)
- Vomiting or vomiting blood
- Sudden weight loss
- Pain or bloating in the stomach after eating
- Weakness or fatigue associated with anaemia (a deficiency in red blood cells)
- Early satiety (become full with small amounts of food)
Note: These symptoms may not necessarily be indicative of gastric and oesophageal cancer and you should seek medical advice for more definitive diagnostic tests as outlined below.
If the doctor is concerned that these symptoms are related to cancer they will recommend any one or combination of tests, these can include:
- Faecal occult blood test – used to detect blood in the stool, which may indicate stomach or other gastrointestinal (GI) cancers (e.g. colorectal cancer)
- Complete blood count (CBC) - a simple blood test used to measure the number of white blood cells, red blood cells, and platelets
- Upper GI series/barium swallow – patient drinks a thick, chalky liquid (barium) that coats the oesophagus and stomach and makes it easier to find abnormal areas on x-ray
- Gastroscopy a doctor inserts a thin tube that contains a camera (called a gastroscope) through the mouth and oesophagus and into the stomach.
- CT scan, ultrasound, and positron emission tomography (PET) scan – imaging tests similar to X-rays
Treatment for gastric and oesophageal cancer
Treatment options depend on a number of factors including the size, location and extent of the tumour, the stage of the disease as well as the general health and age of the patient. The treatments can be any combination of:
Surgery
The type of surgery depends on the extent of the disease. Resection may be used to treat early stomach cancer and this involves removing only the tumour and surrounding tissue. However, the most common treatment for stomach cancer is a Gastrectomy. In this surgery, the entire stomach or part of the stomach is removed.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells.
Chemotherapy
Chemotherapy is a treatment with one or a combination of anti cancer medicines that aim to destroy or control cancer cells. Xeloda is a chemotherapy treatment that is taken orally in tablet form and is fully funded for the treatment of oesophagogastic cancer and is the most commonly used chemotherapy (in combination with a platinum-based chemotherapy) for the first-line treatment of advanced oesophagogastric cancer. And because Xeloda can be taken at home, it allows patients more independence to live their lives, as they spend less time and money travelling to cancer centres to receive treatment. Read more about Xeloda on the site for consumer medicines information (CMI). For more information about Xeloda click on the product logo.
